General Clinical Chemistry Analyzers and Accessories
Abcam Dinaciclib, cyclin-dependent kinase (CDK) inhibitor, 5MG
MW 396.5 Da, Purity >98%. Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 (IC₅₀ values are 3, 1, 1 and 4 nM respectively). Potent DNA replication inhibitor that blocks thymidine incorporation in A2780 ovarian cancer cells (IC₅₀ = 4 nM).
The product is subject to the following: Abcam Restricted Use Statement
Pfanstiehl Inc Ammonium Lactate, Pharmaceutical Grade (A-152-1) - 500G- GMP - CAS: 515-98-0
Ammonium lactate is the chemical combination of lactic acid and ammonium hydroxide.
Abcam Dabrafenib, mutant B-Raf V600E inhibitor, 25MG
MW 519.6 Da, Purity >98%. Potent, ATP-competitive mutant B-Raf V600E inhibitor (IC50 = 0.7 nM), with selectivity versus wild-type B-Raf (IC50 = 5.2 nM) and c-RAf (IC50 = 6.3 nM) in cell-free assays. Antitumor activity *in vivo* in mouse models of B-Raf V600E melanoma.
The product is subject to the following: Abcam Restricted Use Statement
Abcam AZD1480, 50MG
MW 348.76 Da, Purity >98%. Novel, potent and selective small-molecule JAK2 inhibitor (IC₅₀ < 3 nM). It can effectively inhibit tumor angiogenesis and metastasis mediated by STAT3 in stromal cells as well as tumor cells. Also demonstrates >50-fold selectivity for JAK2 over JAK3.
The product is subject to the following: Abcam Restricted Use Statement
Roche Diagnostics CALCIUM BIO HT
Metabolite testing reagent set for quantitative determination of Calcium in aqueous solution or fermentation broth using the Cedex Bio HT instrument.
Abcam ML 204, TRPC4 blocker, 25MG
MW 226.32 Da. Selective TRPC4 channel blocker (IC₅₀ = 0.96 (fluorescence assay) - 2.6 μM (electrophysiological assay)). Selective versus TRPC6 (19-fold) and TRPC5 (9-fold). Essentially inactive at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.
The product is subject to the following: Abcam Restricted Use Statement